Pediatric Hematopoietic Stem Cell Transplantation

author

  • Amir Ali Hamidieh Director of Pediatric Stem Cell Transplant Program, Hematology, Oncology and Stem Cell Transplantation Research Center, Director, Iranian Stem Cell Donor Program (ISCDP), Tehran University of Medical Sciences, Tehran, Iran.
Abstract:

The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in children and adult patients and it is no longer restricted by limited sources of HSCs, donor pools or explicit need for matched family members. Annual number of pediatric HSCTs has been increasing over past two decades and while its growth has become steadier since 2002. Household size and consanguineous marriages in the Middle East means that many pediatric candidates of HSCT can suitable donors among their siblings; however, both of these contributing factors are gradually declining in the region. Iran has been experiencing slower population growth and smaller household sizes since twenty years ago. Hence, according to statements on EMBMT website, Iranian Stem Cell Donor Program (ISCDP) has started its activity in 2010 and has joined Bone Marrow Donors Worldwide (BMDW), in an effort to maximize chances of finding HLA-matched donors in countries in the Eastern Mediterranean Regional Office (EMRO) of World Health Organization (WHO) and beyond. Total body irradiation (TBI) has been used in conditioning from the beginnings of HSCT; however various experiments with non-TBI conditioning regimens have shown an alternative path. Although numerous studies on pediatric HSCT have been published, most patients have had a component of irradiation in their regimens. Long-term detrimental consequences of HSCT, particularly those attributed to TBI, have been continuously studied; endocrine and metabolic abnormalities, growth retardation and short stature and neurocognitive sequel are but a few of these sequel , especially among pediatric recipients. Compared to other studies, non-malignant indications for HSCT constitute a greater proportion of performed HSCTs in Iran; inherited abnormalities of RBCs and thalassemia in particular are responsible for this disparity in part. Keyword:  Hematopoietic Stem Cell, Transplantation.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

pediatric hematopoietic stem cell transplantation

the introduction and evolution of hematopoietic stem cell transplantation (hsct) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. today, hsct is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

full text

Hematopoietic Stem Cell Transplantation for Thalassemia

Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

full text

Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

full text

Hematopoietic Stem Cell Transplantation

The purpose of regenerative medicine [6], especially tissue engineering, is to replace damaged tissue with new tissue that will allow the body to resume normal function. The uniqueness of tissue engineering is that it can restore normal structure in addition to repairing tissue function, and is often accomplished using stem cells [7]. The first type of tissue engineering using stem cells [7] wa...

full text

Hematopoietic Stem Cell Transplantation

Background: One of the major changes in transplantation has been the development of multiple new sources of stem cells (bone marrow, peripheral blood stem cells, and cord blood) for transplant. Because of this proliferation, many now use the term stem cell transplantation (SCT) instead of bone marrow transplantation (BMT) to encompass these various types of transplantation. The aime of the pres...

full text

Hematopoietic stem cell transplantation

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 2  issue 2.3

pages  22- 22

publication date 2014-05-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023